February 25, 2017

Cell Biology and Membrane Transport Processes by Michael Caplan (Eds.)

By Michael Caplan (Eds.)

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FASEB J . 1, 51-54. Cornwell, M. , and Gottesman, M. M. (1991). Binding of drugs and ATP by P-glycoprotein and transport of drugs by vesicles from human multidrug-resistant cells. I n “Molecular and Cellular Biology of Multidrug Resistance in Tumor Cells” (I. B. ), pp. 279-289. Plenum, New York. Currier, S. , Willingham, M. , and Gottesman, M. M. (1989). Deletion and insertion mutants of the multidrug transporter. J . B i d . Chem. 264, 14376-14381. Currier, S. , Kane, S. , Willingham, M. , Cardarelli, C.

VI. MULTIPLE DEDICATED TRANSPORTERS FOR PEPTIDE EXPORT AND INTERCOMPARTMENTAL PROTEIN TRAFFICKING IN EUKARYOTIC CELLS The secretion of a growing number of proteins from animal cells does not appear to involve the standard secretory pathway, for example in- 2. Transmembrane Translocation of Peptides 31 terleukin-la and interleukin- Ip (IL-Ip) and both acidic and basic fibroblast growth factors (for review see Kuchler and Thorner, 1992a). Like yeast a-factor, these proteins do not have any hydrophobic signal peptide, and they are not glycosylated.

265, 3975-3980. Richert, N. , Gottesman, M. , and Pastan, I. (1988). Stability and covalent modification of P-glycoprotein in multidrug-resistant KB cells. Biochemistry 27,7607-7613. 1. T h e Multidrug T r a n s p o r t e r 17 Riordan, J. , Rommens, J. , Lok, S. , Drumm, M. , Iannuzzi, M. , Collins, F. -C. (1989). Identification of the cystic fibrosis gene: Cloning and characterization of complementary DNA. Science 245, 1066-1073. Safa, A. R. (1988). Photoaffinity labeling of the multidrug-resistance-related P-glycoprotein with photoactive analogs of verapamil.

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